A case report on multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 infection.

Key Clinical Message: Early recognition and treatment of Multisystem Inflammatory Syndrome in Children (MIS-C) within the context of COVID-19 infection is crucial for improved outcomes. Prompt intervention with IVIG and steroids leads to significant improvement in a severe case of MIS-C. Clinicians should be vigilant for MIS-C symptoms and initiate timely management. Abstract: We report a case involving a fourteen-year-old male with COVID-19 infection who developed multisystem inflammatory disease. A previously healthy child presented with a history of 10 days of fever and cough, along with diarrhea, and vomiting for 3 days. His COVID-19 infection was confirmed through Polymerase Chain Reaction (PCR), and the laboratory values were remarkable for high levels of C-reactive protein, D-dimers, B-type natriuretic peptide (BNP), and troponin I. He developed circulatory shock on the second day of the presentation and needed inotropic support. Steroids and intravenous immunoglobulin (IVIG) were started in light of Multisystem Inflammatory Syndrome in Children (MIS-C), which improved his condition. Thus, during the management of COVID-19 infection, early detection and a careful clinical characterization for MIS-C are essential.

Clinical Profile, Radiological Findings, and Risk Factors Associated with Pneumonia among Children Admitted in Dhulikhel Hospital.

BACKGROUND: Pneumonia is the commonest lung disease which is a major cause of mortality and morbidity in young children and is a common acute respiratory infection. The presentation varies among the cases. The study was done to know the risk factors, clinical profile, radiological findings, and short-term outcome of the admitted patients with pneumonia between six months to sixteen years at Dhulikhel Hospital. METHODS: A hospital based observational prospective cross-sectional study done in 65 cases over the period of 17 months in children admitted with pneumonia at Pediatrics department of Dhulikhel Hospital. Socio-demographic variables, clinical profile, radiological profile, diagnosis, and short-term outcome were collected and analyzed using descriptive statistics. RESULTS: Out of 65 patients, 76.9% cases were children between six months to five years. The most common clinical presentation was fever (98.5%) followed by cough (86.2%). Crepitation (78.5%) and subcostal retraction (29.2%) were common clinical findings. Disseminated intravascular coagulation, thrombocytopenia, sepsis, and right heart failure were associated with mortality. The requirement of mechanical ventilation, oxygenation, and inotrope support was more likely to have fatal outcome. CONCLUSIONS: Fever and cough were the most common clinical presentation and right middle zone consolidation was the most common finding in children admitted with pneumonia.

Good Quality of Life among People Living with Diabetes Mellitus Visiting the Outpatient Department of Endocrinology in a Tertiary Care Centre.

Introduction: Assessing the quality of life of individuals living with diabetes is crucial for ensuring optimal care and effective management of complications related to their condition. Diabetes is one of the leading causes of preventable mortality and morbidity among non-communicable diseases. The study aims to find out the prevalence of the good quality of life of people living with Diabetes mellitus visiting a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among type 2 diabetic patients visiting the Outpatient Department of Endocrinology in a tertiary care centre from 30 June 2022 to 20 July 2022. Ethical approval was obtained from the Institutional Review Committee. A systematic random sampling technique was used. D-39 questionnaires were administered via face-to-face interviews. Point estimate was calculated at 95% Confidence Interval. Results: Among 118 patients living with diabetes, good quality of life was seen in 97 (82.20%) (75.30-89.10, 95% Confidence Interval). This study found that the energy and mobility domain has the highest mean score of 26.7±7.8. Conclusions: The prevalence of good quality life of people living with Diabetes mellitus was found to be higher than other similar studies done in similar settings. Keywords: diabetes mellitus; patients; quality of life.

Dyslexia Data Consortium Repository: A Data Sharing and Delivery Platform for Research.

Specific learning disability of reading, or dyslexia, affects 5-17% of the population in the United States. Research on the neurobiology of dyslexia has included studies with relatively small sample sizes across research sites, thus limiting inference and the application of novel methods, such as deep learning. To address these issues and facilitate open science, we developed an online platform for data-sharing and advanced research programs to enhance opportunities for replication by providing researchers with secondary data that can be used in their research (https://www.dyslexiadata.org). This platform integrates a set of well-designed machine learning algorithms and tools to generate secondary datasets, such as cortical thickness, as well as regional brain volume metrics that have been consistently associated with dyslexia. Researchers can access shared data to address fundamental questions about dyslexia and development, replicate research findings, apply new methods, and educate the next generation of researchers. The overarching goal of this platform is to advance our understanding of a disorder that has significant academic, social, and economic impacts on children, their families, and society.

Pseudohypoparathyroidism type 1 B mimicking Fahr's disease in a 28-year-old female: A case report.

In virtue of precise clinical history, physical examinations, and biochemical/radiological investigations, pseudohypoparathyroidism can be effectively diagnosed, and its types can be differentiated even without exorbitant tests.

Extensive bilateral intracranial calcifications and seizure in iatrogenic hypoparathyroidism: A case report.

Postoperative permanent hypoparathyroidism can exhibit extensive intracranial calcifications involving basal ganglia, thalamus, cerebellum, and cerebral cortex.